Fig. 3

Bayley-III profiles obtained using FREESIAS and AS-NHS data. Mean Bayley-III raw scores in participants with AS deletion and nondeletion aged 1–12 years, from FREESIAS and the AS-NHS: A Cognitive domain, B Expressive Communication domain, C Receptive Communication domain, D Fine Motor domain, E Gross Motor domain. F EEG data in participants with AS deletion, nondeletion, and TDC from FREESIAS, AS-NHS, and BCH. Axes are plotted on logarithmic scales. G Kaplan–Meyer analysis of cumulative seizure data, stratified by underlying genotype and data source, in participants with AS deletion and nondeletion from FREESIAS and the AS-NHS. The table indicates the number of participants at risk for each group at 12-month intervals. One FREESIAS participant that presented their first seizure at over 18 years old was excluded from this analysis in order to allow for a direct comparison to the AS-NHS analysis that included pediatric population exclusively. AS Angelman syndrome, AS-NHS Angelman Syndrome Natural History Study, Bayley-III Bayley Scales of Infant and Toddler Development® – Third Edition, BCH Boston Children’s Hospital, EEG Electroencephalogram, TDC Typically developing children