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Table 3 Comparisons for accurately and inaccurately classified cases

From: Why are only some children with autism spectrum disorder misclassified by the social communication questionnaire? An empirical investigation of individual differences in sensitivity and specificity in a clinic-referred sample

Mean ± SD

True positives (TP)

False negatives (FN)

False positives (FP)

True negatives (TN)

Comparison

Chi-square/F value

Post hoc analysis (Bonferroni or Fisher’s exact test)

Cognitive functioning (Mean ± SD)

(N = 90)

(N = 43)

(N = 22)

(N = 32)

  

 Full-scale IQ

88.57 ± 23.67

89.97 ± 27.40

92.94 ± 12.74

103.33 ± 16.53

2.83a

TN > TP

 Verbal IQ

86.61 ± 27.47

94.29 ± 23.19

83.06 ± 14.59

105.85 ± 16.56

4.29b

TN > TP

 Non-verbal IQ

86.68 ± 27.28

89.87 ± 25.85

92.56 ± 16.03

101.93 ± 16.78

2.62a

TN > TP

Symptoms severity (Mean ± SD)

 ADOS

  ADOS Comparison Score

7.38 ± 2.54

6.84 ± 2.47

3.12 ± 2.91

4.22 ± 2.76

14.24d

TP > TN and FP, FN > FP

  Social Affect CSSe

6.79 ± 2.27

6.29 ± 1.27

3.67 ± 2.12

4.24 ± 2.46

9.64d

TP > TN and FP

FN > FP

  Restricted and Repetitive Behavior CSSe

7.98 ± 2.43

6.97 ± 2.01

3.00 ± 2.45

4.12 ± 1.73

12.28d

TP & FN > TN and FP

 BASC

  Externalizing problem

61.04 ± 12.54

59.77 ± 12.95

72.00 ± 18.56

68.55 ± 12.43

5.44b

FP > TP and FN

  Internalizing problems

54.03 ± 10.12

56.86 ± 13.71

63.50 ± 13.51

60.70 ± 15.04

3.87a

FP > TP

  Behavioral Symptoms Index

71.51 ± 11.87

65.43 ± 11.93

75.50 ± 10.72

70.32 ± 13.55

3.40a

FP > FN

  Adaptive skillsf

29.21 ± 8.49

37.91 ± 7.99

30.80 ± 5.03

34.83 ± 7.33

10.68d

FN > FP and TP, TN > TP

   Hyperactivity

67.19 ± 12.61

64.14 ± 11.81

71.40 ± 12.63

69.09 ± 13.68

1.59

 

   Aggression

57.63 ± 13.85

56.74 ± 13.23

71.61 ± 20.10

66.70 ± 13.55

6.93c

FP > TP and FN

   Conduct problems

54.59 ± 13.06

54.54 ± 14.24

68.56 ± 17.89

61.79 ± 11.18

5.56b

FP > TP and FN

   Anxiety

54.07 ± 13.27

55.71 ± 14.69

62.65 ± 16.07

55.87 ± 13.55

3.17a

FP > TP

   Depression

58.33 ± 11.89

59.91 ± 13.78

66.20 ± 13.41

65.74 ± 14.40

3.06

 

   Somatization

49.89 ± 9.41

51.57 ± 12.32

54.60 ± 13.49

55.04 ± 16.50

1.52

 

   Atypicality

78.34 ± 17.84

64.86 ± 15.40

77.00 ± 13.97

64.91 ± 13.05

7.89d

TP > TN and FN, FP > FN

   Withdrawal

73.38 ± 12.95

62.51 ± 10.75

69.75 ± 14.45

58.83 ± 14.83

10.08d

TP > TN and FN, FP > TN

   Attention

65.97 ± 8.90

63.00 ± 8.34

66.00 ± 6.18

65.57 ± 7.93

1.10

 

   Adaptabilityf

36.67 ± 8.39

42.49 ± 10.26

32.70 ± 5.80

34.96 ± 7.08

7.16c

FN > TP, FP, and TN

   Social skillsf

32.58 ± 10.01

40.00 ± 7.26

34.55 ± 8.60

37.00 ± 5.82

6.08c

FN > TP

   Leadershipf

31.78 ± 6.95

38.77 ± 6.21

34.00 ± 7.22

37.11 ± 6.81

7.23c

TN and FN > TP

   Activities of daily livingf

30.66 ± 10.72

38.00 ± 9.24

32.35 ± 6.74

37.57 ± 13.19

5.20b

TN and FN > TP

   Functional communicationf

29.03 ± 10.85

38.06 ± 9.90

32.85 ± 6.43

37.04 ± 9.37

8.08d

TN and FN > TP

 VABS

  Communication

65.84 ± 18.13

75.90 ± 19.08

75.94 ± 12.52

81.83 ± 10.44

7.93d

TN and FN > TP

  Daily living skills

67.86 ± 14.39

76.50 ± 14.46

78.00 ± 8.62

80.90 ± 10.51

9.07d

TN, FP, and FN > TP

  Social skills

61.54 ± 13.02

73.24 ± 11.73

68.59 ± 10.79

76.72 ± 8.66

15.84d

TN and FN > TP

  Motor skills

77.76 ± 12.04

81.57 ± 15.68

76.71 ± 20.84

89.38 ± 18.28

1.06

 

  Adaptive behavior composite

64.22 ± 12.73

73.93 ± 12.46

82.53 ± 7.32

77.59 ± 7.95

12.72d

TN, FP, and FN > TP

  1. p value a: p < 0.05; b: p < 0.01; c: p < 0.001; d: p < 0.0001
  2. eThe Calibrated Severity Score (CSS) is a standardized version of ADOS-2 raw total scores aimed to minimize the impact of factors such as age, language, and cognitive ability
  3. fScores are reversed for the Adaptive Scales; lower scores represent poorer skills/performances, and higher scores reflect better skills/performances