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Table 3 Results of the rare variant analyses

From: Correction: Pleiotropy between language impairment and broader behavioral disorders—an investigation of both common and rare genetic variants

Phenotype

ASD

Childhood autism

Asperger’s syndrome

ADHD

Schizophrenia

Gene

Number of variants

P-value

Rho

Number of variants

P-value

Rho

Number of variants

P-value

Rho

Number of variants

P-value

Rho

Number of variants

P-value

Rho

NOP9

63

0.067

0

47

0.165

0

50

0.103

0.5

57

0.233

0

47

0.115

0.3

KMT2D

465

0.250

0

355

0.670

0

368

0.545

1

437

0.737

1

337

0.136

1

RORB

14

0.243

1

11

0.033

1

12

0.894

1

14

0.300

1

11

0.396

1

ABCC13

1

0.138

NA

1

0.180

NA

1

0.584

NA

1

0.383

NA

1

0.079

NA

NDST4

46

0.009

0.4

43

0.189

1

44

0.124

0.4

49

0.238

1

45

0.148

1

FAT3

366

0.291

1

291

0.426

1

293

0.437

1

342

0.150

0.6

280

0.733

0

CMIP

22

0.402

1

18

1.000

1

18

0.637

0

23

1.000

0

17

0.715

0

PALB2

84

0.558

0

65

0.583

0

68

0.835

0

76

0.674

1

66

0.622

0

SCN9A

131

0.094

0

104

0.572

0

110

0.408

0

127

0.148

0

103

0.327

1

MUC6

32

0.911

1

28

0.810

0

29

1.000

1

33

0.843

1

29

0.864

1

NFXL1

26

0.519

1

13

0.695

0

15

0.235

1

17

0.849

1

13

0.559

0

OXR1

41

0.572

0.7

34

0.876

1

34

0.779

1

41

0.365

0

34

0.497

1

ATP2C2

167

0.880

1

120

0.448

0

132

0.288

1

161

0.226

1

116

0.821

1

SETBP1

109

0.850

1

90

0.884

1

92

0.593

1

109

1.000

1

86

0.380

1

CNTNAP2

122

0.527

0

96

0.280

0

104

0.763

1

120

0.235

0.9

93

0.840

0

  1. The number of variants refers to the number of unique variants passing QC and count/frequency thresholds for each gene for each phenotype (this is not the variant count in individuals). Associations with summary statistics in italics were (only) nominally significant
  2. ASD autism spectrum disorder, ADHD attention deficit/hyperactivity disorder, NA not applicable