The microstructural change of the brain and its clinical severity association in pediatric Tourette syndrome patients

Table 2 The association between DSI and the potential risk factors

	Model 1			Model 2
	β	(95% CI)	p-value	β	(95% CI)	p-value
GFA R’t FS tract of precentral gyrus
Age	0.005	(0.001 ~ 0.009)	0.011	0.004	(− 0.001 ~ 0.009)	0.117
Gender	0.004	(− 0.013 ~ 0.021)	0.601
Disease duration	0.003	(− 0.005 ~ 0.011)	0.444
Motor tics score	− 0.001	(− 0.003 ~ 0.001)	0.328
Vocal tics score	− 0.001	(− 0.004 ~ 0.002)	0.373
Total tic score	− 0.001	(− 0.003 ~ 0.001)	0.168
Motor tic score (most severe)	− 0.002	(− 0.004 ~ 0.000)	0.106
Vocal tics score (most severe)	− 0.002	(− 0.005 ~ 0.001)	0.172
Total tics score (most severe)	− 0.002	(− 0.004 ~ 0.000)	0.033	− 0.002	(− 0.004 ~ − 0.0002)	0.023*
RD L’t thalamic radiation of DLPFC
Age	− 0.005	(− 0.008 ~ − 0.002)	0.002	− 0.003	(− 0.007 ~ 0.000)	0.0763
Gender	− 0.006	(− 0.020 ~ 0.009)	0.445
Disease duration	− 0.003	(− 0.008 ~ 0.003)	0.280
Motor tics score	0.001	(0.000 ~ 0.003)	0.043	0.001	(0.000 ~ 0.003)	0.0576
Vocal tics score	− 0.001	(− 0.003 ~ 0.001)	0.369
Total tic score	0.001	(0.000 ~ 0.002)	0.260
Motor tic score (most severe)	0.002	(0.000 ~ 0.003)	0.064
Vocal tics score (most severe)	− 0.001	(− 0.003 ~ 0.001)	0.568
Total tics score (most severe)	0.001	(− 0.001 ~ 0.002)	0.308

Model 1, estimated by simple linear regression. Model 2, estimated by multiple linear regression. *t-value = − 2.407, adjusted R square = 0.169. DLPFC dorsolateral prefrontal cortex, FS frontal-striatal, L’t left, R’t right

ISSN: 1866-1955