Fig. 3

Weighted top caregiver concerns for classic RTT across MECP2 genotypes. Top weighted concerns are listed on the left, with the order presented representing the rank order for all people with classic RTT. MECP2 mutation groups are shown in subsequent columns, arranged with more severe mutations on the left. Abbreviations: EarlyTrunc = Early Truncations; LgDel = Large Deletions; CTT = C-terminal truncations. Heatmap color, concern presentation (> 2.5% in at least one cell), and other abbreviations are as in Fig. 2