Fig. 2
From: A mouse model of ATRX deficiency with cognitive deficits and autistic traits
Fear memory deficits in male and female AtrxNexCre mice. A 3-month-old mice were placed in fear apparatus for 3-minutes and received a foot-shock at 2.5-minutes (red arrow). Mice of each sex and genotype as indicated responded with increased freezing after the foot-shock. B, C AtrxNEXCre mice spent significantly less time freezing compared to control mice at 1.5 and 24 hours after foot shock (1.5 hours male: p<0.0001, F=1.299, Controlmale n=15, AtrxNEXCre male n=13. 1.5 hours female: p<0.0001, F=3.240, Controlfemale n=14, AtrxNEXCre female n=11. 24 hours male: p=0.0002, F=2.019, Controlmale n=9, AtrxNEXCre male n=17. 24 hours female: p<0.0001, F=2.830, Controlfemale n=10, AtrxNEXCre female n=12). Error bars represent +/-SEM (Students t-test, ** p<0.001, ***p<0.0001)