Fig. 3
From: A mouse model of ATRX deficiency with cognitive deficits and autistic traits
AtrxNEXCre mice are hyperactive, show reduced anxiety-like behaviour, and overgroom compared to control mice. A Open field testing of AtrxNEXCre male and female mice shows significantly increased locomotor movement compared to controls as seen over-time in 5-minute intervals and total distance travelled in 1 hour (Male: p<0.0001, F=6.974, Controlmale n=15, AtrxNEXCre male n=20; Female: p<0.0001, F=13.02, Controlfemale n=13, AtrxNEXCre female n=13). B Loss of ATRX in excitatory neurons results in significantly increased velocity of movement (Male p=0.0009, F=3.678, Female p=0.0012, F=4.256). C No alterations in the time spent in the center of the open field was detected, however there was a D decreased distance travelled in the center of the open-field (Male p<0.0001, F=2.691, Female p=0.0004, F=9.146). E Time spent in the dark zone in the light-dark box paradigm (Male: p<0.0001, F=2.746, Controlmale n=15, AtrxNEXCre male n=21, Female: p=0.0003, F=1.016, Controlfemale n=14, AtrxNEXCre female n=14) and the number of entries into the light zone. F Adult AtrxNEXCre mice spend more time grooming than control mice (Male: p=0.0030, F=5.450, Controlmale n=18, AtrxNEXCre male n=15, Female: p=0.0042, F=1.016, Controlfemale n=12, AtrxNEXCre female n=14). Error bars represent +/-SEM. Students t-test, Mann Whitney, or Two-way Anova with Sidak post-hoc (* p<0.05, ** p<0.001, ***p<0.0001)