Fig. 4:
From: A mouse model of ATRX deficiency with cognitive deficits and autistic traits
AtrxNexCre mice exhibit sex-specific deficits in sensory gating. A AtrxNEXCre male mice display an exaggerated auditory startle response compared to controls (p=0.0008, F=18.08), whereas AtrxNEXCre females do not. B AtrxNEXCre male mice exhibit decreased pre-pulse inhibition for Type 1 (30ms, 75db) (p=0.0286, F=1.414), Type 2 (30ms, 80db) (p=0.0261, F=2.048), C Type 3 (75db, 100ms) (p=0.0042, F=1.549) and Type 4 settings (80db, 100ms) (p=0.0008, F=2.510). Controlmale n=14, AtrxNEXCre male n=9, Controlfemale n=11, AtrxNEXCre female n=11. Sex differences were detected in Type 1 (p=0.0125, F=2.955), Type 2 (p=0.0074, F=6.064), and Type 4 settings (p=0.0093, F=1.338). Error bars represent +/-SEM. Students t-test, Mann Whitney, or Two-way Anova with Sidak post-hoc performed when appropriate (* p<0.05, ** p<0.001, ***p<0.0001)