Fig. 5
From: A mouse model of ATRX deficiency with cognitive deficits and autistic traits
Sex-specific altered social behaviour in AtrxNEXCre mice. A Control and AtrxNEXCre mice of both sexes spend more time sniffing the stranger mouse compared to the object in the three-chamber test (Controlmale p<0.0001, AtrxNEXCre male p=0.0017, Controlfemale p<0.0001, AtrxNEXCre female p=0.0005). B Male AtrxNEXCre mice show no preference for a novel mouse in the social novelty portion of the three-chamber test (Controlmale: n=12, AtrxNEXCre male n=13). This test yields inconclusive results for female mice, as the controls did not show a preference for the novel mouse (Controlfemale: n=11, AtrxNEXCre female n=12). C AtrxNEXCre male mice exhibit significantly more tail rattling events in the presence of a stranger mouse (p=0.0013, F=10.35), while AtrxNEXCre female mice do not exhibit this behaviour. D AtrxNEXCre male and female mice are more agitated upon handling, as determined by an elevated agitation score (Male: p<0.0001, F=4.160, Controlmale n=11, AtrxNEXCre male n=18, Female: p=0.0003, F=3.290, Controlfemale n=14, AtrxNEXCre female n=13). E AtrxNEXCre male mice exhibit decreased latency to attack in the juvenile resident intruder paradigm, and AtrxNEXCre female mice do not (Male: p=0.0006, F=2.187, Controlmale n=9, AtrxNEXCre male=10, Female: Controlfemale n=9, AtrxNEXCre female n=10). Error bars represent +/-SEM. Two-way Anova with Sidak post-hoc, Students t-test , or Mann Whitney performed when appropriate (*p<0.05, ** p<0.001, ***p<0.0001).