Fig. 1

Distribution of pathogenic missense mutations within MeCP2. Diagram of the MeCP2 protein with its major domains. The percentage of pathogenic missense mutations that map to each domain is given and was adapted from previously reported analysis of multiple clinical databases [37]. Abbreviations: NTD, N-terminal domain; MBD, methyl-DNA-binding domain; ID, interdomain; TRD, transcription repressor-binding domain; NID, NCoR/SMRT interacting domain; CTD, C-terminal domain