Fig. 1

The Catalytic Subunit: A Representative AlphaFold Structure of the Cα1 catalytic subunit of PKA. The protein N-terminus (MGNAAAAKGSEQES) is highlighted in hot pink, and the more conserved regions of the catalytic subunit are colored in green. B Multiple sequence alignment of the N-terminus for the PKA catalytic subunit isoforms Cα1, Cα2, Cα3, Cβ1, Cγ, and Cχ