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Fig. 5 | Journal of Neurodevelopmental Disorders

Fig. 5

From: Characterization of early markers of disease in the mouse model of mucopolysaccharidosis IIIB

Fig. 5

MPS IIIB mice exhibit normal social approach yet sex-specific altered dominance and aggressive behavior. A Schematic of social approach paradigm. B Distance traveled during all four trials of the social approach task. C Stimulus investigation time during full habituation. D-F Total social preference index (D), stimulus investigation time (E) and social preference index across the 10-min sociability trial (F). G-I Total novelty preference index (G), stimulus investigation time (H) and novelty preference index across the 10-min social novelty trial (I). J Schematic of social dominance tube test paradigm. K Percent of dominant bouts for controls and MPS IIIB mice split across males and females. L Schematic timeline of resident intruder paradigm. M Counts of intruder bouts with scramble attacks per group. N Duration of anogenital sniffing by the resident. O Number of total nose sniffs between residents and intruders. B-I Grouped data are presented as means ± SEM with individual data points presented as open circles. K,M Data are presented as counts. N,O Grouped data presented as boxplots with thick horizontal lines respective group medians, boxes 25th – 75th percentiles, and whiskers 1.5 × IQR. Individual data points are presented as open circles

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