Fig. 6

MPS IIIB mice have larger whole brain and regional volumes with intact tissue integrity. A Whole brain volumes measured by MRI. B Body weight measured prior to MRI. C-F T2-weighted image and whole brain volume of representative control (C,E) and MPS IIIB mouse brains (D,F). G Ratio of cerebellar volume to whole brain volume. H Mean apparent diffusion coefficient for the cerebellum. I,K Representative T2-weighted image (I) and ADC map (K) of control mouse cerebellum (ADC unit, µm²/ms). J,L Representative T2-weighted image (J) and ADC map (L) of MPS IIIB mouse cerebellum (ADC unit, µm²/ms). M Ratio of corpus callosal volume to whole brain volume. N Fractional anisotropy of the corpus callosum as measured by DTI. O,Q Representative T2-weighted image (O) and FA map (Q) of control mouse ­­corpus callosum. P,R Representative T2-weighted image (P) and FA map (R) of MPS IIIB mouse ­­corpus callosum. S Ratio of cortical thickness measurement to whole brain volume. T Representative schematic of cortical thickness measurements indicated by the red line. Data are presented as means ± SEM with individual data points presented as open circles