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Table 3 Gait metrics examined during development and adulthood in MPS IIIB mice compared to control mice

From: Characterization of early markers of disease in the mouse model of mucopolysaccharidosis IIIB

Gait

Metric

Observed p value

Gait

Metric

Observed p value

Development

Adult 30 cm/s

Adult 40 cm/s

Development

Adult 30 cm/s

Adult 40 cm/s

AbsolutePawAngleFore

0.007

0.635

0.150

StanceFactorFore

0.062

0.014

0.617

AbsolutePawAngleHind

0.002

0.537

0.853

StanceFactorHind

0.122

0.257

0.442

BrakeFore

0.00005

0.0001

0.110

StanceFore

0.061

0.210

0.056

BrakeHind

0.381

0.859

0.043

StanceHind

0.474

0.033

0.018

GaitSymmetry

0.372

0.340

0.738

StanceWidthCVFore

0.197

0.175

0.169

MAXdA_dTFore

0.869

0.186

0.209

StanceWidthCVHind

0.096

0.857

0.587

MAXdA_dTHind

0.523

0.275

0.308

StanceWidthFore

0.292

0.221

0.355

OverlapDistanceHind

0.361

0.191

0.153

StanceWidthHind

0.444

0.084

0.302

PawAngleCVFore

0.168

0.187

0.515

StepAngleCVFore

0.323

0.670

0.644

PawAngleCVHind

0.893

0.780

0.351

StepAngleCVHind

0.128

0.227

0.859

PawPlacement PositioningHind

0.014

0.460

0.776

StepAngleFore

0.164

0.552

0.680

Pct_SharedStanceHind

0.167

0.029

0.001

StepAngleHind

0.498

0.468

0.282

Pct_StanceStrideFore

0.019

0.595

0.038

StrideFrequencyFore

0.600

0.326

0.259

Pct_StanceStrideHind

0.366

0.139

0.006

StrideFrequencyHind

0.903

0.507

0.275

Pct_SwingStrideFore

0.019

0.595

0.038

StrideLengthCVFore

0.506

0.712

0.582

Pct_SwingStrideHind

0.366

0.139

0.006

StrideLengthCVHind

0.676

0.516

0.212

PeakPawAreaCVFore

0.637

0.513

0.551

StrideLengthFore

0.609

0.396

0.234

PeakPawAreaCVHind

0.407

0.708

0.798

StrideLengthHind

0.808

0.343

0.300

PeakPawAreaFore

0.161

0.376

0.272

SwingDurationCVFore

0.393

0.304

0.762

PeakPawAreaHind

0.345

0.256

0.322

SwingDurationCVHind

0.807

0.115

0.634

PropelFore

0.135

0.013

0.917

SwingFore

0.205

0.701

0.713

PropelHind

0.957

0.109

0.079

SwingHind

0.671

0.811

0.285