Table 3 Comparison of C601/C602 to PATH for PWS Change from Baseline at 26, and 52 Weeks
Parameter | C601/C602 | PATH for PWS | ||||
|---|---|---|---|---|---|---|
HQ-CT | Measured at | n | LSmean [SE] | n | LSmean [SE] | p-value |
Propensity quintiles | 26 weeks | 108 | -8.3 [0.75] | 195 | -2.5 [0.43] | < 0.001 |
Worst-Case Sensitivity analysis | 26 weeks | 123 | -5.4 [0.97] | 229 | -2.5 [0.39] | 0.006 |
Worst-Case Sensitivity analysis | 52 weeks | 123 | -5.9 [1.04] | 197 | -3.1 [0.43] | 0.015 |
PWSP domain | Measured at | n | LSmean [SE] | n | LSmean [SE] | p-value |
Aggressive Behavior | 52 weeks | 103 | -2.1 [0.31] | 147 | 0.3 [0.26] | < 0.001 |
Anxiety | 52 weeks | 103 | -3.2 [0.35] | 147 | 0.1 [0.30] | < 0.001 |
Compulsivity | 52 weeks | 103 | -3.0 [0.30] | 147 | -0.2 [0.25] | < 0.001 |
Depression | 52 weeks | 103 | -1.0 [0.18] | 147 | -0.1 [0.15] | 0.003 |
Disordered Thinking | 52 weeks | 103 | -1.4 [0.20] | 147 | 0.01 [0.17] | < 0.001 |
Rigidity/ Irritability | 52 weeks | 103 | -3.1 [0.36] | 147 | -0.2 [0.30] | < 0.001 |