Figure 3
From: Mouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndrome
Ubiquitin-positive intranuclear inclusions in neurons and astrocytes of CGG dut knock-in mice. White arrows point to red punctate intranuclear inclusions in pyramidal neurons in motor cortex (A), cortical astrocytes (B) and Bergmann glia in cerebellum (C). Intranuclear inclusions (red) were labeled by immunofluorescence for ubiquitin, neurons (green) for Kv2.1 potassium channels, and astrocytes and Bergmann glia (green) for GFAP. In (B), note an intranuclear inclusion in an adjacent neuron (arrowhead). Nuclei were stained with DAPI. (Adapted from [25]).