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Table 1 Study characteristics of publications in meta-analysis

From: Language delay aggregates in toddler siblings of children with autism spectrum disorder

Publication

HR/LR

Mean age (mo.)

Language delay criteria

Clinical best estimate measures

Language delay (HR versus LR)

MSEL receptive language

MSEL expressive language

Landa and Garrett-Mayer [72]

38/25

24

≤ 1 SD mean: M-CDI or PLS

ADOS

OR = 3.57 (.70–18.16)

χ2 = 1.60, p = .21

n/a

n/a

Iverson and Wozniak [115]

14/18

18

≤ 5th percentile: M-CDI words produced

n/a

OR = 37.00 (1.87–732.72)

χ2 = 8.78, p = .003

n/a

n/a

Gamliel et al. [116]

38/38

24

≤ 2 SD mean: BSID or RDLS

ADOS-G

ADI-R

OR = 7.33 (1.50–35.86)

χ2 = 5.94, p = .015

n/a

n/a

Mitchell et al. [45]

91/52

24

≤ 1.5 SD mean: MSEL or PLS

ADOS

DSM-IV-TR

OR = 1.65 (.50–5.47)

χ2 = .29, p = .59

n/a

n/a

Toth et al. [117]

42/20

21

n/a

ADOS

ADI-R

DSM-IV-TR

n/a

54.50 (6.40)

46.55 (15.60)

48.45 (6.65)

49.07(12.24)

Stone et al. [118]

64/42

16

n/a

n/a

n/a

48.2 (10.8)

43.8 (12.6)

48.7 (10.5)

45.1 (11.1)

Paul et al. [119]

38/31

12

n/a

n/a

n/a

46.1 (7.2) 41.1 (9.7)

47.4 (12.0)

40.8 (10.7)

Curtin and Vouloumanos [120]

31/31

12

n/a

n/a

n/a

45.97 (7.11)

42.16 (7.14)

53.93 (10.47)

49.87 (11.04)

Messinger et al. [66]

989/583

24

n/a

ADOS

MSEL

n/a

27.28 (5.12)

24.63 (5.67)

25.78 (5.29)

24.11 (5.78)

  1. Except where stated, language delay was defined as either receptive or expressive language delay. Odds ratios (ORs) are listed with 95% confidence intervals in parentheses. With the exception of Messinger et al., 2015, which used age equivalent scores at 24 months of age, language scores consisted of T-scores on the Mullen Scales of Early Learning (MSEL), with low-risk siblings without autism spectrum disorder (ASD) listed first and high-risk siblings without ASD listed second. Bolded values indicate significant risk group differences at p < .05. mo. months, HR high-risk siblings without ASD, LR low-risk siblings without ASD, M-CDI MacArthur Communicative Development Inventory, BSID Bayley Scales of Infant Development, RDLS Reynell Developmental Language Scales, PLS Preschool Language Scale, ADOS Autism Diagnostic Observation Schedule, ADOS-G Autism Diagnostic Observation Schedule-General, ADI-R Autism Diagnostic Interview-Revised, DSM-IV-TR Diagnostic and Statistical Manual of Psychiatric Disorders, 4th edition, text revision